liqDB: a small-RNAseq knowledge discovery database for liquid biopsy studies.

Aparicio et al. (2018) Nucleic Acids Research

Number of studies available

Studies uploaded to SRA per year

2018 or later

2016-2017

2014-2015

2012-2013

2011 or before

Example Queries

See this study where they compare healthy subjects with colon and pancreas cancer patients [Go]

See this query where we selected all serum samples from healthy women [Go]

Only interested in one particular miRNA? Have a look at the expression graphs we prepared for hsa-miR-10b-3p [Go]

Comparison : uploaded DLBCL-secreted exosomes samples VS all healthy plasma samples in liqDB (sRNAbench IDs: K56Y0CAK9O26CD6, HDG1DQUKS7SPJ31) [Go]

Fluids Abundance

Top 5

Fluid

N. of Samples

plasma	443
serum	407
whole blood	166
urine	57
Others	194

Number of samples publicly available in SRA

Recent Study Uploads

Diversity and Signature of Small RNA in Different Bodily Fluids using Next Generation Sequencing

SRP: SRP136264
Link to article

Small RNAs are critical components in regulating various cellular pathways. These molecules, which could be tissue-associated or circulating in bodily fluids, have been shown to associate with different tumors. Next generation sequencing on small RNAs is a powerful tool for profiling and discovery, particularly for microRNA (miRNA).In this study, we isolated total RNA from various bodily fluids (blood, leukocytes, serum, plasma, saliva, cell-free saliva, urine and cell-free urine). Then, Illumi[...] Read More
Homo sapiens - small RNA sequencing of plasma

SRP: SRP064104
Link to article

Human plasma miRNAome
Large differences in small RNA composition between human biofluids - 10 biofluids

SRP: SRP136488
Link to article

One goal of Phase 1 of our project is to produce reference profiles of miRNAs and other small RNAs in a large and diverse set of biofluids using a systemic approach. This study contains samples associated with 10 different biofluids, and all data (sequencing data, full alignments, etc.) is openly available. Overall design: 10-12 donors each from 12 biofluids using modified TruSeq protocol with randomized adapters
Circulating miRNAs. isomiRs and small RNA clusters in human plasma and breast milk

SRP: SRP125870
Link to article

Circulating small RNAs. including miRNAs but also isomiRs and other RNA species. have the potential to be used as non-invasive biomarkers for communicable and non-communicable diseases. This study aims to characterize miRNAs. isomiRs and small RNA clusters in biofluids. to compare their profiles. and to help in the establishment of standard guidelines. For this purpose. RNA from plasma and breast milk samples from 15 healthy postpartum mothers was extracted. Small RNA libraries were prepared wi[...] Read More

liqDB: a small-RNAseq knowledge discovery database for liquid biopsy studies.

Aparicio et al. (2018) Nucleic Acids Research

Number of studies available

Studies uploaded to SRA per year

Example Queries

Fluids Abundance

Number of samples publicly available in SRA

Recent Study Uploads

Diversity and Signature of Small RNA in Different Bodily Fluids using Next Generation Sequencing

Homo sapiens - small RNA sequencing of plasma

Large differences in small RNA composition between human biofluids - 10 biofluids

Circulating miRNAs. isomiRs and small RNA clusters in human plasma and breast milk